A new report from the Lancet Commission on Tuberculosis (TB) titled ‘Scientific advances and the end of tuberculosis’ makes several recommendations for how governments should go about fighting the deadly, but curable, disease. Spotlight editor Marcus Low puts the Spotlight on how South Africa’s TB programme is measuring up against the recommendations.
Every year, tens of thousands of people who fall ill with tuberculosis in South Africa are not diagnosed. Because of this, there has been much focus on testing people earlier rather than waiting for them to show up at clinics when they are already sick. One potential solution, explored in a trial called XACT 2, is community-based testing using a point-of-care molecular test. Tiyese Jeranji spoke to experts involved with XACT 2 and unpacks the study’s findings that were recently published in Nature Medicine.
The South African TB Recovery Plan was developed to try and reverse the negative effects of the COVID-19 pandemic on the country’s TB response. On World TB Day, authors from TB Proof (a leading TB activist group) assess how the recovery is going and identify four key areas where further intervention is needed.
The current treatment for drug-susceptible tuberculosis (TB) used in South Africa last for six months, effectively cures TB and is dirt cheap. Two studies in recent years have shown that TB can be cured in four or in some cases even two months, but price and other complications make these treatments tricky to implement. At a conference in Seattle last week, a major trial of an alternative four-month treatment reported disappointing findings. Elri Voigt unpacks the latest findings and asks what the prospects now are for shortening TB treatment.
Diagnosing tuberculosis is difficult in people who struggle to cough up sputum samples – a particular problem in children and people living with HIV. One promising alternative to testing sputum is to test stool. Tiyese Jeranji unpacks the latest developments in this area.
Tuberculosis (TB) can be resistant to treatment with several different drugs. Tests that identify which drugs someone’s TB is resistant to are critical to ensuring that people are not treated with drugs that don’t work for them, especially given the significant side effects associated with some of the drugs. Elri Voigt assesses the state of play in testing for TB drug resistance and the promise of exciting new technologies, such as whole genome sequencing.
In 2015, the World Health Organization recommended a urine test that helps with the detection of tuberculosis (TB) in people living with HIV who are hospitalised or who have compromised immune systems. While uptake of this test in South Africa was initially quite slow, numbers presented at the recent South African TB Conference suggest that the use of the test is now increasing. Tiyese Jeranji reports.
South Africa’s tuberculosis (TB) testing numbers have recovered from dramatic declines in 2020, delegates heard at the opening of the 7th South African TB Conference in Durban. The Department of Health also provided some details of its TB recovery plans and targets. Tiyese Jeranji reports from Durban.
The World Health Organization estimates that every year 40% of people who fall ill with TB globally are not diagnosed. There is thus an urgent need for faster, safe, and more convenient TB tests. The current gold standard for testing still requires people to cough up sputum, something that some people and children, in particular, struggle with. Tiyese Jeranji looks at the potential of a new experimental oral swab TB test.
The COVID-19 pandemic and associated lockdowns have dealt a severe blow to South Africa’s tuberculosis (TB) response. Tiyese Jeranji asked government about its plans to get TB diagnosis, treatment, and prevention services back on track.
The screening, diagnosis, and treatment of tuberculosis (TB) in children remain far from optimal – and in many respects lags behind what can be done for adults. Elri Voigt rounds up five developments in paediatric TB presented at the 52nd Union World Conference on Lung Health.
The World Health Organization estimates that over four million of the almost ten million people who fell ill with tuberculosis in 2020 were not diagnosed. One obstacle to more people being diagnosed is the fact that most current tests require people to produce sputum – something children and some people living with HIV find difficult. Tiyese Jeranji looks at a new fingerstick blood test that may help diagnose more people quicker.
