Interview: Prof Lynette Denny reflects on an extraordinary life of service

Interview: Prof Lynette Denny reflects on an extraordinary life of serviceProfessor Lynette Denny in her home with a picture of her late mother, Mary. PHOTO: Nasief Manie/Spotlight
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It could be said that Professor Lynette Denny’s career has been one of selfless dedication to bettering and saving women’s lives in South Africa, particularly those from poor areas. But that would not quite capture the reality, for Denny’s ground-breaking academic and clinical achievements in cervical cancer prevention do not stem from a toiling spirit of self-sacrifice. Hers is a demeanour of exuberance.

Since 1995, when Denny first started exploring pap smear alternatives in collaboration with Columbia University in New York, she has pursued doing what she loves best even as it consumed most of her days. Friends describe her as a “hermit” and she admits, “I’m very bad. I’ve always been very bad. You know, but balance does not lead to excellence.”

Professor Lynette Denny is head of the Department of Obstetrics and Gynaecology at the University of Cape Town (UCT) with a lifelong career in cervical cancer research. PHOTO: Nasief Manie/Spotlight

At 63, Denny heads the Department of Obstetrics and Gynaecology at the University of Cape Town (UCT). She has served as chairperson to the non-profit organisation Rape Crisis and was a driving member of the team that pioneered South Africa’s Thuthuzela Care Centres (TCCs) in 2006, which is a critical part of the country’s anti-rape strategy aimed at reducing secondary victimisation. Peers recall her driving to Groote Schuur Hospital – the academic public hospital affiliated to UCT – at night to operate on rape survivors.

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“I always say, I’m the member of society who keeps the toilets flushing,” she says. “You know, in other words, we do the same thing. We do it every day and we do it forever. We teach people around ourselves and then eventually, when I go off into the sunset, it will continue. It’s consistency. There’s a time for rage, to be indignant, and angry… But the key thing for me, you have to be a trunk. You got to stand firm in your belief.”

Time to think

Speaking from her apartment in Green Point, Cape Town, Denny’s words are matter-of-fact, with an occasional reflective bent as she gazes back at her life’s work. Without flinching, Denny relays that her days are numbered. She has metastatic (stage IV) breast cancer, which has spread to her spine.

“Essentially, I have advanced notice of things coming to an end,” she says. “So I’m getting my life in order. Now, I have time to think about what I’ve done with my life. It’s a journey, you know?”

Asked about her calm in the face of this grave certainty, she shrugs. “Actually, I recently did one of those personality type tests and came out an engineer. Yes, I am pragmatic,” she says. “We like order.”

Last week, Denny travelled to Pretoria in a wheelchair to accept the Order of the Baobab, South Africa’s highest accolade for citizen excellence. Despite her painful spine, Denny stood next to President Cyril Ramaphosa as he draped the silver medal around her neck.

President Cyril Ramaphosa bestows the Order of Baobab in Silver to Professor Lynette Denny at the Sefako M Makgatho Presidential Guesthouse in Tshwane. PHOTO: airus Mmutle/GCIS
President Cyril Ramaphosa bestows the Order of Baobab in Silver to Professor Lynette Denny at the Sefako M Makgatho Presidential Guesthouse in Tshwane. PHOTO: Jairus Mmutle/GCIS

Finding balance

Inside her apartment, on the kitchen counter, is a paper sheet with a half-painted rose and paintbrushes. In a recent bid to introduce some “balance” into her life, Denny has taken up art classes. On the walls are family photos of her parents and four siblings, and her two nieces. Bright, tapestried cushions adorn her sofa. They were made by her late mother, Mary. It was Mary, a fiery apartheid opponent who left school in standard eight, who instilled in Denny the sense of social justice that would come to propel her career.

Denny’s formative years were in Durban.

“The strongest influence was my mum,” she says. “So my mum’s mum was a nurse and her father, in retrospect, probably had bipolar disease. He was an alcoholic, and he used to beat my grandmother. So my mum had an absolute phobia about men who beat women. My mother, from a very young age, said to me [that] no man will ever stand over you. Or be better than you and you will get educated.”

She recalls early brushes with the injustices of apartheid. “There used to be what were called ‘the blackjacks’, who would come into your house at two o’clock in the morning to raid the staff quarters to see if they had children or boyfriends or friends or anyone else over. There were very strict rules about who could be there. And every time this happened, we would all wake up and my mum [would] be running down and screaming at them, hitting them with a broom. She would be furious and it made a really big impression on me.”

Another influence was Alice Khuzwayo, she says. “She brought me up for the first 10 to 12 years of my life. She was a wonderful woman and I still love her very deeply, although she’s long since dead. I remember going to her room and noticing that they had a toilet that was like, it was like you had to squat on it, like an Asian-type toilet, not like what we had, a sitting flush toilet. So you know, there were so many incidents of great and small insults to black people.”

Prof Denny at her desk busy painting
Professor Lynette Denny is known for her groundbreaking work on cervical cancer in South Africa. PHOTO: Nasief Manie/Spotlight

Life-saving research

Leaning back in her desk chair, Denny recalls doing her first HPV (human papillomavirus) detection study involving 3 000 women from a caravan set up in Khayelitsha outside Cape Town for her PhD, which she completed in 2000.

Today, Denny runs a research clinic in five shipping containers with ten staff in Site B in Khayelitsha, where women have access to free life-saving HPV screening and treatment. Denny glows, adding that just the day before the interview, she finally got official municipal permission to extend the clinic after having first applied a year back.

“At the moment we have five shipping containers and then a pre-fab building,” she says. “Now we’re going to build [on] that. We’ll put in toilets, our own toilets, and extra rooms for examining patients, and a nice patient lounge. We need more space, more pretty space. I always think that a physical environment is critical to a feeling of wellbeing and being respected.”

Having nurtured her project in Khayelitsha from infancy for over twenty years, there are many special memories. “I mean, one of the things I learned, for instance, through working in Khayelitsha – just a small anecdote,” she says. “We connected up with the traditional healers and women and I used to go and visit them and talk to them about the work we were doing.” Denny says one of the things she noticed among her patients was their feelings around the vagina and the vulva. “You know, [that] it’s a shameful, dirty thing. And it belongs to my partner anyway, who is usually a male. I picked this up very strongly and realised that we had to change that narrative.

“I mean, the vagina and the vulva and the cervix are the most beautiful part of the body. It’s where life is given, where great pleasure is experienced, and also terrible violence. And so I got hold of this woman who was a praise singer – and it’s very unusual to find black women who are praise singers. We did this exercise where we created vision boards. So everybody got a piece of newspaper and scissors and glue and magazines and pencils, and everybody put down all their thoughts about their vaginas and we pulled it all together, and this praise singer came up with this poem,” Denny recalls.

“And this was before The Vagina Monologues. And I’ve met Eve Ensler, by the way. I don’t think I have the words exactly right, but the poem was something like ‘The vagina is an apricot. The vagina is like a strawberry. The vagina is beautiful. Kings, Queens, and graduates have been born through the vagina, even Nelson Mandela.’ Isn’t that beautiful? Even Nelson Mandela was born through the vagina… And we started singing it and we went on walks around the township, singing it. You know, and [to] every woman who came, I said, be proud, you know, be proud.”

Professor Lynette Denny greeting President Cyril Ramaphosa with an elbow bump. She travelled to Pretoria in a wheelchair to accept the Order of the Baobab, South Africa’s highest accolade for citizen excellence. PHOTO: Jairus Mmutle/GCIS

Be of service

Denny’s hands gesture as she explains the intricacies of HPV. German virologist Harald zur Hausen discovered the link between HPV and cervical cancer, she says, for which he was awarded the Nobel Prize in Physiology or Medicine in 2008. There are over 170 strains of HPV, most of which resolve spontaneously but two types – HPV16 and HPV18 – are known to cause legions, which may result in cervical cancer if not detected in time.

An estimated 10 000 women living in South Africa are diagnosed with cervical cancer each year, of whom 6000 will die from the disease – mostly those from low-resourced areas, without access to timely screenings.

“To cut a long story short,” she says. “Because I mean, we’ve done a lot of work. We are evaluating what we call screen and treat. So, we recruit women aged 30 to 65 and we perform an HPV test on her using this new method. It’s what we call a ‘point of care’ test. It gives you a result in one hour and tells you whether this woman has one of 14 high-risk types of HPV.” Denny says she thinks this will be her last study. “I’ve had enough now,” she says.

“Then if suitable, we treat the woman in the same visit with what we call thermal coagulation, which is a device with a sort of stem and you burn the cervix using it for about 20 seconds at a hundred degrees and that destroys the precancerous lesions. It’s painless. But I mean, we don’t use that language when we talk to patients because they’ll jump off the bed and never come back. We do have a way of explaining it that makes it less scary,” she says.

Her current research involves new artificial intelligence technology called Automated Visual Evaluation (AVE) – a machine-learning-based algorithm that assesses photographs of the cervix for signs of cancer.

“Don’t ask me the technicalities,” she says. “I don’t understand it. I’m over 60. But you take a photograph of the cervix and send it up into the cloud and it sends down within three minutes whether the cervix is at risk or not.”

Concluding the interview, Denny says, “And I think my lasting – [or] what I would like to impart to those who follow me when I leave, is to be able to be of service to your community is a great privilege. It’s not a duty. It’s not a burden. Immersing myself in the Khayelitsha community was just so liberating; to lose the sense of othering, to feel connected to humanity like that has been so enriching. I recommend it.”