In-depth: Landmark moment as AI beats humans in reading X-rays for TB

In-depth: Landmark moment as AI beats humans in reading X-rays for TB

“The results are in: artificial intelligence (AI) outperforms humans at reading chest X-rays for signs of tuberculosis,” proclaimed a recent newsletter of the Stop TB Partnership. Tiyese Jeranji spoke to a variety of experts about the landmark study behind this proclamation and asked what AI-aided X-ray interpretation may mean for countries like South Africa with high TB burdens.

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COVID-19: What tests are available in SA and which ones to use?

COVID-19: What tests are available in SA and which ones to use?

The different types of COVID-19 tests are far from equal. Picking a test is generally a matter of speed versus accuracy and, most importantly, why you need a test and when. What are the limitations of these tests? Is there any quality control? What are the chances of false positives and false negatives? Elsabé Brits surveys the landscape of tests available in South Africa and asks which type is most appropriate in what situation.

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Editorial: HIV prevention injection should be fast-tracked like COVID-19 vaccines

Editorial: HIV prevention injection should be fast-tracked like COVID-19 vaccines

Findings of two large phase III clinical trials first presented in 2020 showed a new HIV prevention injection to be highly effective. Yet, experts expect that the injection will only reach clinics in late 2022 or early 2023. If the rhetoric about bringing the urgency of COVID-19 to HIV is to mean anything, these timelines should be made shorter.

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In-depth: What will it take to bring HIV prevention injections to SA’s clinics?

In-depth: What will it take to bring HIV prevention injections to SA’s clinics?

An antiretroviral injection administered every two months has been shown to be highly effective in preventing people from getting HIV in two large trials. Catherine Tomlinson asks what needs to happen before these injections become available to people in South Africa.

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We need to vaccinate 90% of over-35s – Madhi

We need to vaccinate 90% of over-35s – Madhi

Government can avoid the overwhelming of health services and minimise death in an anticipated fourth COVID-19 wave in November/December by getting 90% of people in South Africa over 35 years old vaccinated before then. Life could then return to normal by Christmas, even with ongoing SARS-CoV-2 circulation, contends vaccinologist Professor Shabir Madhi.

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In-depth: The state of congenital syphilis in SA

In-depth: The state of congenital syphilis in SA

Over the last few years reported cases of congenital syphilis in South Africa have increased. This, accompanied by little or lack of notification, makes its management a challenge. Tiyese Jeranji reports on what congenital syphilis is, its management as well as gaps in management.

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Editorial: Government should explain plans in wake of J&J setback

Editorial: Government should explain plans in wake of J&J setback

Jabs from Johnson & Johnson were central to plans to scale up South Africa’s COVID-19 vaccination programme. With news that a first consignment of two million doses cannot be used, it is critical that government play open cards with the public about its revised vaccination plans and timelines and what steps it is taking to procure more vaccines faster.

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In Focus: Global strategy to end Cryptococcal Meningitis in people living with HIV

In Focus: Global strategy to end Cryptococcal Meningitis in people living with HIV

Cryptococcal meningitis is the second biggest killer of people living with HIV after tuberculosis (TB). Now, a global initiative, the Ending Cryptococcal Meningitis Deaths by 2030 Strategic Framework aims to get the gold standard drug to treat cryptococcal meningitis – flucytosine – registered in countries that need it. Amy Green reports.

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Trial of potentially variant-proof vaccine ongoing in Western Cape

Trial of potentially variant-proof vaccine ongoing in Western Cape

An experimental COVID-19 vaccine currently in Phase I trials being run by the University of Cape Town has a unique design that might allow it to offer better protection against current and future variants of the SARS-CoV-2 virus. Elri Voigt provides an update on the trial and unpacks the science behind this vaccine candidate.

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COVID-19: What is the correct way to report vaccine-related adverse events?

COVID-19: What is the correct way to report vaccine-related adverse events?

Phase two of South Africa’s COVID-19 vaccine rollout is underway and members of the public are being asked to report any mild, moderate or severe adverse events experienced after receiving their jabs. Adele Baleta explains what the correct way is to report adverse events after vaccination.

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How vaccine safety is monitored in SA

How vaccine safety is monitored in SA

Strict monitoring and surveillance systems for the safety of all vaccines, including those for COVID-19, are in place during vaccine trials as well as once vaccines are rolled out more widely. Adele Baleta takes a look at how vaccine-related adverse events are monitored in South Africa.

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