In South Africa, taking HIV treatment means taking one or more antiretroviral tablets a day. People in some other countries have the additional option of treatment in the form of two injections administered every two months. Elri Voigt unpacks why long-acting HIV treatment is not available in South Africa and asks why the push for HIV prevention jabs has been so much stronger than that for HIV treatment jabs.
Taking antiretrovirals to prevent HIV infection mostly still involves swallowing one or more pills a day. Some long-acting products that work for a month or two at a time have been approved but are not yet in wide use in South Africa. As delegates gathered for the 25th International AIDS Conference (AIDS 2024) last week, Elri Voigt takes stock of the latest developments in this fast-moving field.
With the remarkable success of antiretroviral treatment people living with HIV in South Africa are generally living much longer than they did two decades ago. As a result, more people with HIV are also now living with non-communicable diseases (NCDs) such as diabetes and hypertension. Accordingly, the need to better integrate HIV and NCD services was a hot topic at the recent Southern African HIV Clinicians Society conference in Cape Town. Elri Voigt reports.
Newly announced results of a pivotal phase 3 trial have demonstrated the effectiveness of a new treatment for gonorrhoea. The medicine, zoliflodacin, is the first new drug developed to treat gonorrhoea in over 30 years. More than half of the 930 patients in the trial were from South Africa. Catherine Tomlinson reports.
The 11th SA AIDS conference, recently held in Durban, highlighted the worrying fact that key HIV numbers such as treatment coverage are much lower in children than in adults. But as Elri Voigt reports, conference delegates also heard about new treatments and guidelines that will make life easier for kids and the exciting potential of several new long-acting experimental treatments.
Last year Spotlight reported that pilot projects testing out a new HIV prevention injection and a vaginal ring in South Africa would start early in 2023. Yet, as delegates gathered for the SA AIDS Conference in Durban last week, those pilots hadn’t yet started. Alicestine October and Elri Voigt have the latest on the state of play with these critical projects.
South Africa’s HPV vaccination programme has by all accounts been a resounding success over the last decade, likely helping to prevent many cases of cervical cancer. But the programme has suffered major setbacks due to COVID-19-related disruptions and in addition to getting it back on track, some argue vaccine eligibility should be expanded to include boys as well as older girls and women newly infected with HIV. Amy Green takes stock of the country’s HPV vaccination efforts.
The South African Health Products Regulatory Authority has authorised an injection containing the antiretroviral cabotegravir for use to prevent HIV infection, according to drugmaker ViiV Healthcare. Laura Lopez Gonzalez reports.
HIV prevention pills are becoming more widely available in South Africa and the country is set to soon start piloting the use of an HIV prevention injection. But merely having these tools available in clinics and other places does not mean people will use them. Thabo Molelekwa asked several experts what behaviour change communications should look like in this new era of HIV prevention.
South Africa is expected to begin piloting the HIV prevention injection early next year as one of several projects that experts hope will reveal the answers to some of the biggest questions about the future of the shot – who will deliver the injection, where, and how to sell people on the idea that just six shots a year could protect them from HIV. Laura Lopez Gonzalez reports.
As a rebellious teenager growing up in the British town of Harpenden, Professor Helen Rees would sneak out to attend anti-apartheid talks. Today, she is a renowned scientist and chair of South Africa’s medicines regulator. Biénne Huisman chatted to Rees about her career, prioritising women’s reproductive health, and her role at the South African Health Products Regulatory Authority.
South Africa is expected to begin piloting the every-other-month HIV prevention shot early next year, according to the international medicine financing initiative Unitaid. New modelling shows that the injection could prevent as many as 52 000 new HIV infections in the next two decades. But to be cost-effective in South Africa, the research argues, the price of the injection must fall to levels drugmaker ViiV Healthcare says are unrealistic. Laura Lopez Gonzalez reports.
