Antibiotic slashes risk of drug-resistant TB in kids, finds major SA study

Tuberculosis (TB) preventive therapy has been transformed in recent years, with treatment duration having been cut from six or more months to just three or one. Progress in developing new treatments to prevent drug-resistant forms of TB has however lagged behind, especially in children. Elri Voigt unpacks findings from a major new TB prevention study presented at the Union World Conference on Lung Health last week and plans for another important preventive therapy trial set to start soon.

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Interview: “The only good TB bacillus is a dead one”, says UCT’s Prof Valerie Mizrahi

Professor Valerie Mizrahi, a world-leading tuberculosis researcher and director of the Institute of Infectious Disease and Molecular Medicine at the University of Cape Town, is retiring at the end of the year. Biénne Huisman sat down with Mizrahi to talk about her journey in TB research, passing the baton to a new generation of researchers, and how she helped build a research ecosystem that brings together specialists across the basic, clinical, and public health sciences.

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TB contact tracing helps save lives – this is how it works in SA

Tracing the close contacts of people ill with tuberculosis (TB) and offering them TB preventive therapy is part of South Africa’s strategy to fight TB. A recent analysis found that such an approach of tracing household contacts and providing them with TB preventive treatment is cost-effective and would – by 2025 – cut deaths by 35% among household contacts of all ages and people living with HIV. In light of these new findings, Tiyese Jeranji assesses the state of contact tracing in South Africa’s public healthcare system.

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Opinion: Yes! We can end TB in South Africa

While there is a long way to go, there has been important progress in South Africa’s response to tuberculosis (TB) and 2023 is set up to be a watershed year for the fight against the disease both globally and in South Africa. As we commemorate World TB Day, let us all pledge to make this year’s theme a reality – “Yes! You and I can end TB”, write Gaurang Tanna and Yogan Pillay.

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Opinion: World TB Day – let’s seize this moment to change the status quo

Like with SARS-CoV2, we need to rapidly implement and scale-up effective tuberculosis (TB) prevention interventions, while remaining adaptive to prevailing needs across the country. If we choose to pursue this more deliberate approach to TB prevention in South Africa, World TB Day will no longer be an admission of insufficient progress, but a celebration of defeating our long-standing battle with this curable disease, writes Dr Kavindhran Velen and Professor Salome Charalambous.

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