INTERVIEW: “Guys, I think that’s a new variant” – de Oliveira reflects on two years chasing the virus

South African bioinformatics expert Professor Tulio de Oliveira was recently honoured with Time Magazine’s 100 most influential people award. Biénne Huisman sat down with him to talk about his part in the discovery of new COVID-19 variants, his chats with the President, and the treasure trove of scientific research excellence in Africa.

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In-depth: Surgery catch-up hamstrung by shortage of ICU nurses

Hospitals in South Africa have been put under immense strain over the past two years as beds were filled with COVID-19 patients and elective surgeries had to be put on hold. To make things worse, pre-existing shortages of intensive care trained nurses and other critical staff were exacerbated by healthcare workers themselves contracting SARS-CoV-2 and falling ill or having to isolate themselves. Tiyese Jeranji explores how Gauteng and the Western Cape are catching up on elective surgeries and asks what is being done about the underlying problem of staff shortages.

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Experts unpack cabinet’s easing of restrictions

This week, South Africa’s COVID-19 regulations were amended to state that people who have tested positive for SARS-CoV-2 who do not have symptoms do not have to self-isolate. People who have tested positive and who do have COVID-19 symptoms have to isolate for seven days unless a longer period is recommended by a medical practitioner. Chris Bateman spoke to some local experts about the reasoning behind the changes and what other changes may be warranted.

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COVID-19: What tests are available in SA and which ones to use?

The different types of COVID-19 tests are far from equal. Picking a test is generally a matter of speed versus accuracy and, most importantly, why you need a test and when. What are the limitations of these tests? Is there any quality control? What are the chances of false positives and false negatives? Elsabé Brits surveys the landscape of tests available in South Africa and asks which type is most appropriate in what situation.

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COVID-19: Clearer picture of long COVID slowly emerging

The first long COVID study conducted in South Africa found that 82% of patients still had persistent or new symptoms a month after their discharge from hospital. However, much is still unknown about what exactly causes this and how to alleviate the suffering, which is becoming an increasing health burden across the globe. Elsabé Brits surveyed the latest evidence and asked local experts to place it in context.

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How well is SA’s chronic medicines distribution system working?

Having to collect one’s medicines at overcrowded public sector clinics with long queues can be time-consuming, disruptive, and, these days, may expose one to a risk of contracting SARS-CoV-2. Thabo Molelekwa takes stock of South Africa’s centralised chronic medicines dispensing and distribution programme, the Department of Health’s system for allowing more people to collect their chronic medicines closer to their homes or workplaces.

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Healthcare workers in the third wave: “We are living in the shadows of death”

It’s been over a year since COVID-19 first hit South Africa. Since then, many people have been living in constant fear and many have lost loved ones. Frontline healthcare workers had no choice but to face their fears if they were to keep doing the life-saving work they were trained for. Amy Green and colleagues explore the emotional toll that South Africa’s third wave of COVID-19 is taking on healthcare workers.

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COVID-19: Will vaccinated people in South Africa need booster shots?

The two vaccines used in South Africa’s vaccination programme, those from Johnson & Johnson and Pfizer/BioNTech, have both been shown to be highly effective against COVID-19, particularly in preventing hospitalisation and death. But protection may wane over time and new variants may or may not render these vaccines less effective. Adele Baleta unpacks what we do and do not know about the potential need for booster shots and surveys some of the studies that will help fill the gaps.

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