COVID-19: The role of next-generation vaccines in immunity

Indications are that the virus that causes COVID-19 is going to continue evolving and escaping the protection against infection people already have. Researchers are working on next-generation vaccines tailored to fight off specific versions of the virus, like the Omicron sub-lineages BA.4 and BA.5. But can these new vaccines be tested and produced fast enough to keep up with the rapidly changing virus? Aisha Abdool Karim asked some local experts.

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COVID-19: Reinfections amid ‘complex mix of immunity’

Omicron and its sub-variants have been dominating new surges of SARS-CoV-2 infections around the world and were behind South Africa’s fifth wave. The BA.4 and BA.5 sub-lineages unveiled yet more surprises about the evasive nature of these ever-emerging forms of SARS-CoV-2. They also hold clues for what to expect next and how to prepare. Aisha Abdool Karim reports.

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COVID-19: What role for masks, sanitising, and ventilation in the new normal?

South Africa’s fifth wave of COVID-19 infections was comparatively small and is already abating. As with the fourth wave, infection was much less likely to result in hospitalisation or death than in the first three waves. In light of these changes in the pandemic, Aisha Abdool Karim asks what the “new normal” should look like when it comes to mask-wearing, ventilation, hand sanitising, and other preventive measures.

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We need to vaccinate 90% of over-35s – Madhi

Government can avoid the overwhelming of health services and minimise death in an anticipated fourth COVID-19 wave in November/December by getting 90% of people in South Africa over 35 years old vaccinated before then. Life could then return to normal by Christmas, even with ongoing SARS-CoV-2 circulation, contends vaccinologist Professor Shabir Madhi.

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COVID-19 in kids: What have we learnt one year later?

It has been over a year since the world saw the first confirmed case of COVID-19, yet the science behind the virus’ physical impact on children remains relatively unclear. Kathryn Cleary spoke to two experts in paediatrics and immunology to get an update on what we have learnt so far.

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COVID-19: The evolving science behind long-COVID

A study published in the Lancet medical journal confirms that the health effects of COVID-19 can linger months after someone has ‘recovered’. Kathryn Cleary asked local experts about the underlying science and whether the South African public healthcare system is ready for so-called long-COVID.

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