HIV vaccine research set to change focus in wake of Mosaico disappointment

Top South African HIV clinicians are setting their sights on different approaches to finding an HIV vaccine after the “disappointing” news that the Mosaico trial was stopped early because the vaccine did not show any efficacy. The search for an HIV jab now seems set to pivot from vaccines that induce T-cell immunity to ones that induce B-cell immunity. Adele Baleta unpacks what that means and the reasoning behind it.

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As with COVID-19, the effects of TB can linger long after it is cured

According to the World Health Organization, of the roughly 10 million people who fall ill with TB annually, over 80% survive, in most cases due to a six-month treatment course. Unfortunately, as with long COVID, being cured is not always the last hurdle and many people go on to struggle with post-TB lung disease. Tiyese Jeranji asked local experts about this sometimes-neglected area of TB care.

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OPINION: 2022’s health budget decisions in review

Health budgets have the power to advance access to healthcare for millions of people in South Africa. This year, however, as the health sector and the economy recovered from the worst of the COVID-19 pandemic and a volatile global environment, the South African government missed opportunities to provide the financial resources to protect access to healthcare for the most vulnerable. Matshidiso Lencoasa unpacks how the past year’s budget choices will affect key public health services.

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Analysis: How well did SAHPRA do in 2022?

The South African Health Products Regulatory Authority has often made the headlines in recent years – be it in relation to COVID-19 vaccines, access to ivermectin, the approval of an HIV prevention injection, or most recently the clearing of inherited backlogs. Catherine Tomlinson assesses the state of South Africa’s medicines regulator as 2022 draws to a close.

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KwaZulu-Natal doing well compared to other provinces but some health services still a challenge

KwaZulu-Natal clinics are outperforming facilities monitored in other provinces on various indicators and health services in the province have improved year-on-year, but some marginalised groups continue to have a hard time accessing healthcare services. This is according to the latest provincial report from community-led monitoring project Ritshidze. Nthusang Lefafa spoke to several NGOs about the findings and asked the province’s health department for their response.

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Face to Face: Prof Helen Rees on SAHPRA, women’s rights, and her appetite for justice

As a rebellious teenager growing up in the British town of Harpenden, Professor Helen Rees would sneak out to attend anti-apartheid talks. Today, she is a renowned scientist and chair of South Africa’s medicines regulator. Biénne Huisman chatted to Rees about her career, prioritising women’s reproductive health, and her role at the South African Health Products Regulatory Authority.

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Opinion: Mental health screening for people with TB will change lives and boost SA’s TB response

According to some estimates, over a third of tuberculosis (TB) patients have high levels of psychological distress and a quarter have an alcohol use disorder. Following an eye-opening project in KwaZulu-Natal, Atlantic Institute Tekano Fellow Amanda Fononda argues that a diagnosis of an illness (such as TB) should be accompanied by mental health screening for treatment readiness, adherence, and overall well-being.

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