A humanist with an unblinking gaze – Professor Ntobeko Ntusi takes the hot-seat at the South African Medical Research Council

Professor Ntobeko Ntusi may be softspoken, but he is not afraid to stand by his strongly held views. As he is set to take up the hot-seat at the country’s primary health research funder, he tells Spotlight’s Biénne Huisman about his background and his priorities for the new job.

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HIV vaccine research set to change focus in wake of Mosaico disappointment

Top South African HIV clinicians are setting their sights on different approaches to finding an HIV vaccine after the “disappointing” news that the Mosaico trial was stopped early because the vaccine did not show any efficacy. The search for an HIV jab now seems set to pivot from vaccines that induce T-cell immunity to ones that induce B-cell immunity. Adele Baleta unpacks what that means and the reasoning behind it.

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We need to vaccinate 90% of over-35s – Madhi

Government can avoid the overwhelming of health services and minimise death in an anticipated fourth COVID-19 wave in November/December by getting 90% of people in South Africa over 35 years old vaccinated before then. Life could then return to normal by Christmas, even with ongoing SARS-CoV-2 circulation, contends vaccinologist Professor Shabir Madhi.

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Behind the scenes: How the first 500 000 vaccine doses administered in SA were secured

When South Africa’s rollout of the AstraZeneca vaccine was put on hold in early February, a scramble ensued to ensure healthcare workers could be protected. Chris Bateman spoke to Professor Glenda Gray about the behind-the-scenes negotiations that helped secure 500 000 doses of the Johnson & Johnson vaccine – almost all of which have now been used in the Sisonke study.

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