Women in Health: Petro Terblanche – the farm girl from Brits who steered Africa’s first mRNA vaccine

When Professor Petro Terblanche joined biotechnology start-up Afrigen three years ago, she had no idea that the team she was heading up would create the continent’s first mRNA vaccine. But that wasn’t the first time Terblanche had been at the forefront of cutting-edge scientific work. Aisha Abdool Karim spoke to her as part of Spotlight’s Women in Health series.

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Women in Health: Francesca Conradie – from HIV to groundbreaking TB research

Dr Francesca Conradie knew she wanted to be a doctor when she was eight years old. Now, 50 years later, she is a pioneer in the field of tuberculosis (TB) and led a landmark trial that changed how drug-resistant TB is treated. Aisha Abdool Karim spoke to her about the reasons behind her switch from HIV research to TB, her initial surprise at the remarkable NiX trial results, and the man who has shaped her life – her father.

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Experts weigh in on the potential of ultrasound for diagnosing TB in kids

Tuberculosis can be challenging to diagnose in children, especially very young children. This is because it is difficult for them to cough up the sputum required by gold standard molecular tests and because they have fewer TB organisms in their sputum than adults. X-ray screening may be part of the solution, but it has shortcomings. Following some interesting recent study findings, Tiyese Jeranji asks what role lung ultrasound may have in improving TB detection in kids.

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COVID-19: The role of next-generation vaccines in immunity

Indications are that the virus that causes COVID-19 is going to continue evolving and escaping the protection against infection people already have. Researchers are working on next-generation vaccines tailored to fight off specific versions of the virus, like the Omicron sub-lineages BA.4 and BA.5. But can these new vaccines be tested and produced fast enough to keep up with the rapidly changing virus? Aisha Abdool Karim asked some local experts.

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PART 2 – How can we reduce incidence of cerebral palsy in SA?

It is estimated that around half of medical negligence claims against the South African government are cerebral palsy-type claims. Apart from the direct impact on infants and families, cerebral palsy thus also has a major impact on health budgets. In this second article in a two-part series, Elri Voigt asks what can be done to reduce the incidence of cerebral palsy in the country. In part 1 we looked at what we know about cerebral palsy in South Africa.

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Intimate partner violence in SA – is it getting worse and how do we tackle it?

A third or even up to half of women and girls in South Africa aged 15 and older have either experienced physical or sexual intimate partner violence (IPV). Some experts say South Africa almost has a perfect storm of IPV drivers. Elsabé Brits unpacks some of the recent findings published in a landmark Lancet Psychiatry Commission on interpersonal violence and asks experts how we can address this in South Africa.

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What should the TB priorities be in the new NSP?

The period covered by South Africa’s National Strategic Plan (NSP) for HIV, TB, and STIs 2017 – 2022 will soon come to an end. Against the backdrop of another World TB Day, Tiyese Jeranji asked several local tuberculosis experts what they think the TB priorities should be as South Africa develops an NSP for the next five years.

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Analysis: Is SA on course to solve its TB diagnosis problem?

It is estimated that over 100 000 of the over 300 000 people who fall ill with TB in South Africa every year are not diagnosed. As a result, improving TB screening and testing has become a high priority in South Africa’s TB response. Coinciding with World TB Day 2022, Spotlight editor Marcus Low examines new information shared by the National Department of Health and assesses the state of the country’s TB case-finding efforts.

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