COVID-19: The role of next-generation vaccines in immunity

Indications are that the virus that causes COVID-19 is going to continue evolving and escaping the protection against infection people already have. Researchers are working on next-generation vaccines tailored to fight off specific versions of the virus, like the Omicron sub-lineages BA.4 and BA.5. But can these new vaccines be tested and produced fast enough to keep up with the rapidly changing virus? Aisha Abdool Karim asked some local experts.

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COVID-19: Reinfections amid ‘complex mix of immunity’

Omicron and its sub-variants have been dominating new surges of SARS-CoV-2 infections around the world and were behind South Africa’s fifth wave. The BA.4 and BA.5 sub-lineages unveiled yet more surprises about the evasive nature of these ever-emerging forms of SARS-CoV-2. They also hold clues for what to expect next and how to prepare. Aisha Abdool Karim reports.

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COVID-19: What role for masks, sanitising, and ventilation in the new normal?

South Africa’s fifth wave of COVID-19 infections was comparatively small and is already abating. As with the fourth wave, infection was much less likely to result in hospitalisation or death than in the first three waves. In light of these changes in the pandemic, Aisha Abdool Karim asks what the “new normal” should look like when it comes to mask-wearing, ventilation, hand sanitising, and other preventive measures.

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