On June 5 2026, an HIV prevention injection will for the first time become available at some of South Africa’s public sector clinics. In this Spotlight special briefing, Marcus Low and Elri Voigt pull together all you need to know about this “breakthrough” jab.
A Supreme Court of Appeal ruling in October 2025 cleared the way for specially trained and permitted pharmacists to dispense antiretroviral medicines without a doctor’s script. Seven months later, no pharmacists are yet providing these services. Catherine Tomlinson explores the reasons for the delay.
By March 2027, the health department aims to have 1.5 million people living with HIV on a new programme where they can get a six-month supply of antiretroviral medicines at a time. Early indications suggest that implementation of the programme is slow and uneven, reports Christina Pitt.
The number of people in South Africa on antiretroviral treatment remained roughly unchanged from 2024 to 2025, according to just-published estimates from the leading mathematical model of HIV in the country. This suggests that the disruption of US aid for HIV services has slowed the growth of our HIV treatment programme, but the impact so far is not as severe as some researchers feared it might be. Marcus Low reports.
Along dusty roads in northern KwaZulu-Natal, Biénne Huisman speaks to youth leaders, community mentors and leading scientists who are collaborating to bring a groundbreaking HIV prevention jab to this area where HIV infection rates remain stubbornly high.
Bukhosi Mdletshe works as clinic manager at the Ensingweni clinic in in KwaZulu-Natal, and in his words, paying his dues to the rural community that raised him. Sue Segar and Thom Pierce spent some time with Mdletshe for Spotlight’s Rural Health Heroes series.
Antiretroviral therapy has shifted HIV from a fatal to a chronic condition. But neuropsychiatrists say it is imperative for people living with the virus to start treatment immediately as the “duration of untreated exposure” may cause irreversible brain damage and impact long-term cognitive health. Biénne Huisman reports.
A cutting-edge, South African-led HIV vaccine trial built on decades of research recently kicked off in Cape Town. Elri Voigt unpacks what exactly is being studied, and how the resilience, tenacity and urgency of a group of dedicated South African researchers made it possible.
The year’s biggest health story by far has been the cuts to US aid for health and US support for health research. But it’s also been a year of important HIV prevention developments, NHI court cases, ongoing crises in some of our provincial health departments, and some first steps toward accountability for the corruption at Tembisa Hospital.
The National Health Laboratory Service has provided HIV, TB, syphilis and cholesterol data, which Spotlight and GroundUp obtained through the Promotion of Access to Information Act.
As World AIDS Day 2025 swings by, CAPRISA Director Professor Salim Abdool Karim reflects on the frantic days following this year’s unprecedented cuts to health aid and research funding from the US, arguing that the deliberate disruptiveness was designed to be cruel. Nonetheless, he argues, our HIV response must now forge ahead on a path that is more affordable, sustainable and independent.
From the first reported cases of HIV in 1981 to the latest breakthroughs in long-acting prevention, this Spotlight timeline traces key moments in the global and South African response to the virus. It highlights scientific milestones, political controversies, activism, and the human stories that shaped one of the most significant public health challenges of our time.
