Are two medicines instead of three the future of HIV treatment?

One of the biggest breakthroughs in HIV treatment in the 1990s came when three different antiretrovirals were used together, suppressing viral replication in multiple ways and preventing the development of drug resistance. Now, trials are showing that certain combinations of just two antiretrovirals might be as good as three, potentially bringing an end to a quarter of a century of triple therapy dominance. Elri Voigt reports.

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Opinion: We should make it much easier for people to start and stay on HIV treatment

The top priority in our HIV programme should be to make it as easy as possible for people to start and stay on treatment. Yet, as a number of provincial reports released this year by community monitoring group Ritshidze have shown, there are many healthcare system factors that work directly against this objective. Spotlight editor Marcus Low considers some of the potential solutions.

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Opinion: Funding must be allocated to treat drivers of HIV

If South Africa wants to strengthen the prevention arm of its HIV programme, which it definitely should, providing comprehensive sex education in schools and training teachers to deliver this curriculum will be vital. It is important that the HIV/AIDS Life Skills Grant, as one of the key pieces of a broader HIV prevention strategy, be supported and strengthened, argue Mbali Baduza and Julia Chaskalson.

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In-depth: New licenses could spark manufacture of COVID-19 pills in Africa

Pharmaceutical companies Merck and Pfizer recently announced early results from clinical trials showing that two new antiviral medicines are highly effective in reducing COVID-19 deaths and hospitalisation. The Medicines Patent Pool then announced licensing deals with both companies that will allow for generic versions of the two drugs to be produced. Catherine Tomlinson unpacks the licenses and asks whether generic versions of these pills might now be made in Africa.

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Circumcision reducing HIV infections but COVID-19 caused setbacks

A UNAIDS report published earlier this year estimates that just under 4.5 million men and boys accessed voluntary male medical circumcision (VMMC) services in South Africa by the end of 2019 with 47% of these having been performed from 2016 to 2019. Thabo Molelekwa reports on the impact COVID-19 has had on VMMCs and the challenges related to resuming this service in the country.

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HPV: What is happening with SA’s other relatively new vaccine programme?

In 2014, South Africa launched an HPV vaccination campaign targeting 9-year-old public school learners in Grade 4. It involves delivering two doses of vaccine six months apart. Laura Owings asks how the campaign is going and what recent real-world HPV vaccine effectiveness data from the United Kingdom might mean for South Africa.

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In-depth: Is government ready to invest in mental health?

Mental health does not have its own ring-fenced budget and given huge inefficiencies in our mental health spending, we need to be strategic on where and how we spend the little we have. Alicestine October unpacks what a new government-commissioned mental health investment case framework can mean for access to equitable and quality mental health services in the country. 

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