HIV vaccine research set to change focus in wake of Mosaico disappointment

Top South African HIV clinicians are setting their sights on different approaches to finding an HIV vaccine after the “disappointing” news that the Mosaico trial was stopped early because the vaccine did not show any efficacy. The search for an HIV jab now seems set to pivot from vaccines that induce T-cell immunity to ones that induce B-cell immunity. Adele Baleta unpacks what that means and the reasoning behind it.

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Opinion: Changing the law on sex work will save lives, we must see it through

In December 2022, the Minister of Justice, Ronald Lamola, set into motion a public participation process on the laws that govern sex work in South Africa. Marlise Richter & Pamela Chakuvinga point out that while the Bill published for public comment in December is very short, it will do something quite extraordinary if it does become law – it will fully decriminalise sex work. This, they argue, is a process we must see through.

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As with COVID-19, the effects of TB can linger long after it is cured

According to the World Health Organization, of the roughly 10 million people who fall ill with TB annually, over 80% survive, in most cases due to a six-month treatment course. Unfortunately, as with long COVID, being cured is not always the last hurdle and many people go on to struggle with post-TB lung disease. Tiyese Jeranji asked local experts about this sometimes-neglected area of TB care.

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OPINION: 2022’s health budget decisions in review

Health budgets have the power to advance access to healthcare for millions of people in South Africa. This year, however, as the health sector and the economy recovered from the worst of the COVID-19 pandemic and a volatile global environment, the South African government missed opportunities to provide the financial resources to protect access to healthcare for the most vulnerable. Matshidiso Lencoasa unpacks how the past year’s budget choices will affect key public health services.

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Pilot programme improving access to mental health services for kids in Khayelitsha

Earlier this year, the annual Child Gauge indicated that child and adolescent mental health services in South Africa are in crisis – mostly due to inadequate resources. How to best provide such services within the constraints of our public healthcare system is an open question. Tiyese Jeranji visited the Michael Mapongwane Community Health Centre in Khayelitsha where a pilot project aimed at improving kids’ access to mental health services is showing encouraging results.

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Analysis: How well did SAHPRA do in 2022?

The South African Health Products Regulatory Authority has often made the headlines in recent years – be it in relation to COVID-19 vaccines, access to ivermectin, the approval of an HIV prevention injection, or most recently the clearing of inherited backlogs. Catherine Tomlinson assesses the state of South Africa’s medicines regulator as 2022 draws to a close.

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