Interview: From a pig farm in Zim to star HIV researcher- Prof LGB reflects on her remarkable journey

Inside Professor Linda-Gail Bekker’s office a bookshelf is stacked with titles on general medicine, HIV and tuberculosis. Against the bookshelf, a mannequin leans dressed in a white doctor’s coat, sparkling tiara and pink Venetian mask, with a stethoscope protruding from her pocket. Known to colleagues as LGB, Bekker is one of South Africa’s top HIV researchers. Biénne Huisman chatted to Bekker about her remarkable career, finding new ways to reach young people, her love of both art and science and the thinking behind the slogan “get ripped, get prepped”.

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Lead poisoning part 2: Scientists find toxic metals in kitchenware

In part one of this Spotlight special series on lead poisoning, Jesse Copelyn explored new research suggesting that lead exposure is far more damaging to cardiovascular health than previously estimated. In part two, he takes a look at the sources of lead poisoning in South Africa, where the metal has been found in products ranging from cooking pots to serving plates.

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Antibiotic slashes risk of drug-resistant TB in kids, finds major SA study

Tuberculosis (TB) preventive therapy has been transformed in recent years, with treatment duration having been cut from six or more months to just three or one. Progress in developing new treatments to prevent drug-resistant forms of TB has however lagged behind, especially in children. Elri Voigt unpacks findings from a major new TB prevention study presented at the Union World Conference on Lung Health last week and plans for another important preventive therapy trial set to start soon.

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Interview: “Someone had to do it”, says SA TB activist on Time 100 list

At the age of 19 Phumeza Tisile contracted multidrug-resistant tuberculosis. For four years she battled the disease, losing her hearing in the process. At one stage, a doctor told her to visit a priest and prepare her soul for death. Recently, Tisile (now 33) made it on to TIME magazine’s 2023 TIME100 Next list, as one of 100 emerging leaders round the world who are “shaping the future and defining the next generation of leadership”. Sue Segar chatted to Tisile about her remarkable journey.

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In-depth: SA’s remarkable TB clinical trial capacity

Several of the world’s most important tuberculosis clinical trials of the last two decades were done in part or entirely in South Africa. Tiyese Jeranji chatted to some leading researchers about where the country’s clinical trial capacity comes from and what is needed to maintain and improve it.

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In-depth: How do long-acting HIV treatments work?

Researchers have been trying to develop antiretroviral medicines that can last for weeks, months or even years per dose. Two such long-acting formulations have been approved in South Africa, but several more are on the horizon. Elri Voigt explores the science behind what makes a formulation long-acting and takes a look at some particularly exciting prospects.

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In-depth: What new WHO TB numbers mean for SA

An estimated 54 000 people died of tuberculosis in South Africa in 2022 and around 280 000 fell ill with the disease, according to just-released figures from the World Health Organization. Catherine Tomlinson unpacks the figures and what they mean for the country’s TB response.

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