Over the last decade, there’s been growing evidence that people can have TB without having any symptoms. But there is still much uncertainty over how such asymptomatic TB functions in the body and how infectious it is. An ambitious study, set to be conducted in South Africa and Indonesia, is trying to find some answers. Elri Voigt reports.
TB can be cured, but ridding the body of the bug often takes many months and usually requires taking four or more different medicines. In this Spotlight special briefing, Elri Voigt zooms in on what makes the TB bacterium so hard to beat.
For centuries, it was believed that tuberculosis spread primarily when a vulnerable person spends hours in a poorly ventilated space with someone infectious. But new findings suggest that much TB transmission also occurs through casual contact. Biénne Huisman reports.
The world desperately needs an effective TB vaccine to reduce the illness and death still being caused by the centuries’ old bacterium. Chris Bateman visited a study site in Paarl where a promising experimental TB vaccine is now being tested as part of a large multi-country clinical trial.
Just over a month after US President Donald Trump implemented a 90-day freeze of all foreign assistance, the future looks very uncertain for tuberculosis research. Among others, a large TB research programme that was worth up to $200 million was axed last week. Elri Voigt reports.
Some patients at KwaZulu-Natal hospitals are donating lung tissue for use in TB research. Sue Segar tracks what happens to these tissue samples and explores why these samples are so important to unlocking the mysteries of what the TB bacterium does inside the human body.
An estimated 56 000 people in South Africa and 1.25 million around the world died of TB in 2023, according to just-published figures from the WHO. This means that in 2023 TB overtook COVID-19 as the top infectious disease killer on the planet. Marcus Low unpacks the new numbers.
Pregnant women are typically excluded from clinical trials of new TB medicines. This has led to a lack of solid scientific evidence on how best to treat women who fall ill with TB while they are expecting. Tiyese Jeranji asked local TB experts about the problem and puts the spotlight on a recent study that broke the mould by opening its doors to pregnant women.
Most tuberculosis (TB) tests still require a trip to the clinic. Now, new technology has made it possible to test people at home. This could be a big deal for South Africa, where much TB goes undiagnosed. Tiyese Jeranji unpacks the findings and implications of a recent study into such TB home testing.
In this open letter to Minister of Health Dr Joe Phaahla, TB activists call for the disease to be made a political priority and demand multisectoral departmental accountability. They outline six demands for implementation by the end of this year. The letter was submitted on the final day of the South African TB Conference being held this week in Durban.
Besides preventing illness and death, tuberculosis prevention therapy is estimated to be highly cost effective. Yet, uptake of the medication is not what it could be in South Africa. Tiyese Jeranji asks how much has changed since the Department of Health last year decided to make TB prevention therapy much more widely available.
South Africa is one of only six countries to ever meet their “fair share target” for funding tuberculosis (TB) research, according to a new report. In absolute terms however, South Africa’s contribution is small change compared to investments into TB research made by the top two contributors, the United States government and the Bill and Melinda Gates Foundation. Catherine Tomlinson unpacks what the report tells us about investment in TB research in South Africa.
